Draws for the next round of Europe's second-tier international club-level tournament were held Friday in Nyon, Switzerland.
Last 16 matches will be played on March 10 and 17.
The final will be held at St Jakob-Park in the Swiss city Basel on May 18.
Fenerbahce will play the first leg at home on March 10 and the second leg will be played in Portugal on March 17.
Europa League Round of 16 fixtures are as follows:
Shakhtar Donetsk (Ukraine) vs Anderlecht (Belgium)
Basel (Switzerland) vs Sevilla (Spain)
Villarreal (Spain) vs Bayer Leverkusen (Germany)
Athletic Bilbao (Spain) vs Valencia (Spain)
Liverpool (England) vs Manchester United (England)
Sparta Prague (Czech Republic) vs Lazio (Italy)
Borussia Dortmund (Germany) vs Tottenham Hotspur (England)
Fenerbahce (Turkey) vs Braga (Portugal)
