Istanbul rivals Fenerbahce and Galatasaray trail on 18 points each after drawing 1-1 with each other on Sunday.
Necip Uysal put Besiktas ahead in the 14th minute before Antalyaspor's Samuel Eto equalized seven minutes later.
In the 27th minute, Mario Gomes put Besiktas ahead again and scored another in the second half before Olcay Sahan and Cenk Tosun added their names to the scoresheet.
Gomez leads the top scorers' list with eight goals, followed by Eto'o and Bursaspor's Tomas Necid on seven goals.
Turkish Super League's week nine results:
Caykur Rizespor 0-2 Akhisar Belediyespor
Eskisehirspor 1-3 Kayserispor
Kasimpasa 0-1 Bursaspor
Genclerbirligi 1-0 Osmanlispor
Gaziantepspor 1-0 Mersin Idmanyurdu
Medicana Sivasspor 0-2 Trabzonspor
Medipol Basaksehir 4-0 Torku Konyaspor
Fenerbahce 1-1 Galatasaray
Antalyaspor 1 – 5 Besiktas
