The Istanbul club's Danish center-back Simon Kjaer will miss the match as the 26-year-old regular is suspended.
In addition Fenerbahce veteran, Gokhan Gonul, 31, is expected to miss the game.
Antalyaspor's biggest threat against Fenerbahce will be Cameroonian star forward Samuel Eto'o. The former Barcelona forward has scored 13 goals in 19 league matches this season.
Fenerbahce's Brazilian striker Fernandao is in good form, scoring four goals in the last two weeks in the league.
The match at Antalya Stadium will kick-off at 8 p.m. local time (1800 GMT).
Galatasaray will host Torku Konyaspor on Saturday. The Lions want to get over the 3-2 loss against Osmanlispor last week.
Lions' defender Hakan Balta is suspended; another regular, Semih Kaya, has been ruled out through injury.
Galatasaray are in third spot with 33 points. The Lions' German forward Lukas Podolski has resumed full training, recovering from a muscle injury which kept him out of action for almost a month.
The match at Turk Telekom Arena will start at 7 p.m. (1700 GMT).
Title contenders Besiktas will meet Gaziantepspor at Basaksehir Fatih Terim Stadium in Istanbul on Sunday.
Besiktas' mid-season signings -- Ukrainian goalkeeper Denys Boyko, Spanish center-back Alexis and Brazilian center-back Marcelo -- may make their debuts.
The Black Eagles are now in the second place with 41 points and have two games in hand.
The match will kick-off at 7 p.m. (1700 GMT).
Friday:
Osmanlispor vs Medicana Sivasspor
Antalyaspor vs Fenerbahce
Saturday:
Kayserispor vs Mersin Idmanyurdu
Bursaspor vs Medipol Basaksehir
Galatasaray vs Torku Konyaspor
Sunday:
Caykur Rizespor vs Eskisehirspor
Akhisar Belediyespor vs Trabzonspor
Besiktas vs Gaziantepspor
Monday:
Kasimpasa vs Genclerbirligi
