Borussia Dortmund appear closest of the Europa League's final 16 to qualification to the quarter-finals after the German side beat Tottenham Hotspur 3-0 on Thursday night.
A first-half goal from Pierre-Emerick Aubameyang and two from Marco Reus in the second-half secured a definitive victory against the north London club in the first leg of the round.
In Istanbul, Fenerbahce triumphed over Portugal's Braga through Mehmet Topal's late shot - the only goal of the closely fought match. The game was the Super Lig leader's 12th straight home win.
A clash between two former European champions, Liverpool and Manchester United, saw Liverpool win 2-0 in the first European clash between the rivals. Elsehwhere, Shakhtar Donetsk triumphed over Belgian side Anderlecht although the visitors got a valuable away goal in Ukraine.
Second leg matches will be played on March 17.
Europa League Round of 16 first leg results:
Shakhtar Donetsk 3-1 Anderlecht
Basel 0-0 Sevilla
Borussia Dortmund 3-0 Tottenham Hotspur
Fenerbahce 1-0 Braga
Villarreal 2-0 Bayer Leverkusen
Athletic Bilbao 1-0 Valencia
Liverpool 2-0 Manchester United
Sparta Prague 1-1 Lazio
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