| 1 | |  Buxton FC | 42 | 23 | 12 | 7 | 80 | 38 | 42 | 81 | G18:00 | 26/03/22 | R 37  Witton Albion 0 Buxton FC 3 B17:00 | 02/04/22 | R 38 Buxton FC 0 Lancaster City 0 G17:00 | 09/04/22 | R 39 Buxton FC 3 Grantham Town 0 B17:00 | 16/04/22 | R 40 Mickleover FC 3 Buxton FC 3 G17:00 | 18/04/22 | R 41 Buxton FC 1 Matlock Town 0 M17:00 | 23/04/22 | R 42 Stalybridge Celtic 1 Buxton FC 0 |
| 2 | |  South Shields | 42 | 23 | 9 | 10 | 71 | 40 | 31 | 78 | B17:00 | 02/04/22 | R 38 G´borough Trinity 1 South Shields 1 G17:00 | 09/04/22 | R 39 South Shields 4 Stalybridge Celtic 0 G17:00 | 16/04/22 | R 40 FC United Of Manchester 0 South Shields 1 M17:00 | 18/04/22 | R 41 South Shields 2 Whitby Town 3 M17:00 | 23/04/22 | R 42 Grantham Town 1 South Shields 0 M21:45 | 26/04/22 | R semifinal South Shields (5) 1 Warrington Town (6) 1 |
| 3 | |  Matlock Town | 42 | 21 | 10 | 11 | 59 | 36 | 23 | 74 | B17:00 | 02/04/22 | R 38 Matlock Town 0 Morpeth Town 0 G17:00 | 09/04/22 | R 39 Basford United 0 Matlock Town 1 B17:00 | 16/04/22 | R 40 Matlock Town 0 Nantwich Town 0 M17:00 | 18/04/22 | R 41 Buxton FC 1 Matlock Town 0 G17:00 | 23/04/22 | R 42 Matlock Town 2 Warrington Town 0 M21:45 | 26/04/22 | R semifinal Scarborough Athletic 2 Matlock Town 1 |
| 4 | |  Scarborough Athletic | 42 | 21 | 11 | 10 | 61 | 48 | 13 | 74 | B17:00 | 09/04/22 | R 39 Ashton United FC 0 Scarborough Athletic 0 G17:00 | 16/04/22 | R 40 Scarborough Athletic 2 G´borough Trinity 0 G17:00 | 18/04/22 | R 41 Morpeth Town 0 Scarborough Athletic 3 G17:00 | 23/04/22 | R 42 Scarborough Athletic 5 Radcliffe FC 2 G21:45 | 26/04/22 | R semifinal Scarborough Athletic 2 Matlock Town 1 G17:00 | 02/05/22 | R final Scarborough Athletic 2 Warrington Town 1 |
| 5 | |  Warrington Town | 42 | 20 | 11 | 11 | 67 | 47 | 20 | 71 | B17:00 | 09/04/22 | R 39 Warrington Town 1 Stafford Rangers 1 G17:00 | 16/04/22 | R 40 Atherton Collieries AFC 0 Warrington Town 2 G17:00 | 18/04/22 | R 41 Warrington Town 2 Witton Albion 0 M17:00 | 23/04/22 | R 42 Matlock Town 2 Warrington Town 0 G21:45 | 26/04/22 | R semifinal South Shields (5) 1 Warrington Town (6) 1 M17:00 | 02/05/22 | R final Scarborough Athletic 2 Warrington Town 1 |
| 6 | |  Bamber Bridge | 42 | 21 | 6 | 15 | 67 | 59 | 8 | 69 | B21:45 | 29/03/22 | R 33 Bamber Bridge 2 Mickleover FC 2 G17:00 | 02/04/22 | R 38 Bamber Bridge 2 Witton Albion 0 G17:00 | 09/04/22 | R 39 Hyde United 0 Bamber Bridge 4 G17:00 | 16/04/22 | R 40 Bamber Bridge 3 Morpeth Town 2 G17:00 | 18/04/22 | R 41 Lancaster City 0 Bamber Bridge 1 B17:00 | 23/04/22 | R 42 Bamber Bridge 1 Nantwich Town 1 |
| 7 | |  Whitby Town | 42 | 19 | 9 | 14 | 57 | 50 | 7 | 66 | M21:45 | 29/03/22 | R 33 Stalybridge Celtic 2 Whitby Town 1 B17:00 | 02/04/22 | R 38 Whitby Town 0 Basford United 0 M17:00 | 09/04/22 | R 39 Radcliffe FC 4 Whitby Town 3 G17:00 | 16/04/22 | R 40 Whitby Town 2 Ashton United FC 0 G17:00 | 18/04/22 | R 41 South Shields 2 Whitby Town 3 M17:00 | 23/04/22 | R 42 Whitby Town 1 G´borough Trinity 2 |
| 8 | |  Stafford Rangers | 42 | 15 | 16 | 11 | 55 | 39 | 16 | 61 | M18:00 | 26/03/22 | R 37 South Shields 2 Stafford Rangers 0 G17:00 | 02/04/22 | R 38 Stafford Rangers 4 Grantham Town 1 B17:00 | 09/04/22 | R 39 Warrington Town 1 Stafford Rangers 1 M15:00 | 16/04/22 | R 40 Stafford Rangers 0 Basford United 1 M17:00 | 18/04/22 | R 41 Nantwich Town 2 Stafford Rangers 1 G17:00 | 23/04/22 | R 42 Stafford Rangers 5 Ashton United FC 0 |
| 9 | |  FC United Of Manchester | 42 | 18 | 7 | 17 | 66 | 57 | 9 | 61 | B18:00 | 26/03/22 | R 37 Mickleover FC 3 FC United Of Manchester 3 G17:00 | 02/04/22 | R 38 FC United Of Manchester 2 Atherton Collieries AFC 0 M17:00 | 09/04/22 | R 39 Morpeth Town 1 FC United Of Manchester 0 M17:00 | 16/04/22 | R 40 FC United Of Manchester 0 South Shields 1 G17:00 | 18/04/22 | R 41 Ashton United FC 0 FC United Of Manchester 3 M17:00 | 23/04/22 | R 42 FC United Of Manchester 0 Hyde United 2 |
| 10 | |  Morpeth Town | 42 | 17 | 10 | 15 | 67 | 59 | 8 | 61 | B17:00 | 02/04/22 | R 38 Matlock Town 0 Morpeth Town 0 M21:45 | 05/04/22 | R 22 Witton Albion 3 Morpeth Town 2 G17:00 | 09/04/22 | R 39 Morpeth Town 1 FC United Of Manchester 0 M17:00 | 16/04/22 | R 40 Bamber Bridge 3 Morpeth Town 2 M17:00 | 18/04/22 | R 41 Morpeth Town 0 Scarborough Athletic 3 B17:00 | 23/04/22 | R 42 Atherton Collieries AFC 1 Morpeth Town 1 |
| 11 | |  Lancaster City | 42 | 17 | 5 | 20 | 44 | 51 | -7 | 56 | G18:00 | 26/03/22 | R 37 Lancaster City 1 Nantwich Town 0 B17:00 | 02/04/22 | R 38 Buxton FC 0 Lancaster City 0 M17:00 | 09/04/22 | R 39 Lancaster City 0 Witton Albion 1 M14:30 | 16/04/22 | R 40 Stalybridge Celtic 3 Lancaster City 0 M17:00 | 18/04/22 | R 41 Lancaster City 0 Bamber Bridge 1 M17:00 | 23/04/22 | R 42 Mickleover FC 3 Lancaster City 1 |
| 12 | |  Mickleover FC | 42 | 15 | 10 | 17 | 54 | 65 | -11 | 55 | B21:45 | 29/03/22 | R 33 Bamber Bridge 2 Mickleover FC 2 G17:00 | 02/04/22 | R 38 Warrington Town 0 Mickleover FC 1 M17:00 | 09/04/22 | R 39 G´borough Trinity 2 Mickleover FC 0 B17:00 | 16/04/22 | R 40 Mickleover FC 3 Buxton FC 3 G17:00 | 18/04/22 | R 41 Basford United 0 Mickleover FC 1 G17:00 | 23/04/22 | R 42 Mickleover FC 3 Lancaster City 1 |
| 13 | |  Nantwich Town | 42 | 14 | 10 | 18 | 46 | 52 | -6 | 52 | M18:00 | 26/03/22 | R 37 Lancaster City 1 Nantwich Town 0 G17:00 | 02/04/22 | R 38 Nantwich Town 2 Scarborough Athletic 1 B17:00 | 09/04/22 | R 39 Nantwich Town 2 Atherton Collieries AFC 2 B17:00 | 16/04/22 | R 40 Matlock Town 0 Nantwich Town 0 G17:00 | 18/04/22 | R 41 Nantwich Town 2 Stafford Rangers 1 B17:00 | 23/04/22 | R 42 Bamber Bridge 1 Nantwich Town 1 |
| 14 | |  Stalybridge Celtic | 42 | 15 | 7 | 20 | 51 | 59 | -8 | 52 | G21:45 | 29/03/22 | R 33 Stalybridge Celtic 2 Whitby Town 1 M17:00 | 02/04/22 | R 38 Stalybridge Celtic 0 Radcliffe FC 2 M17:00 | 09/04/22 | R 39 South Shields 4 Stalybridge Celtic 0 G14:30 | 16/04/22 | R 40 Stalybridge Celtic 3 Lancaster City 0 B17:00 | 18/04/22 | R 41 Hyde United 2 Stalybridge Celtic 2 G17:00 | 23/04/22 | R 42 Stalybridge Celtic 1 Buxton FC 0 |
| 15 | |  Ashton United FC | 42 | 13 | 12 | 17 | 50 | 59 | -9 | 51 | M17:00 | 02/04/22 | R 38 Ashton United FC 0 Hyde United 3 B21:45 | 05/04/22 | R 33 Ashton United FC 2 Atherton Collieries AFC 2 B17:00 | 09/04/22 | R 39 Ashton United FC 0 Scarborough Athletic 0 M17:00 | 16/04/22 | R 40 Whitby Town 2 Ashton United FC 0 M17:00 | 18/04/22 | R 41 Ashton United FC 0 FC United Of Manchester 3 M17:00 | 23/04/22 | R 42 Stafford Rangers 5 Ashton United FC 0 |
| 16 | |  Radcliffe FC | 42 | 15 | 6 | 21 | 56 | 73 | -17 | 51 | B21:45 | 29/03/22 | R 33 Matlock Town 0 Radcliffe FC 0 G17:00 | 02/04/22 | R 38 Stalybridge Celtic 0 Radcliffe FC 2 G17:00 | 09/04/22 | R 39 Radcliffe FC 4 Whitby Town 3 M15:00 | 16/04/22 | R 40 Witton Albion 2 Radcliffe FC 1 G17:00 | 18/04/22 | R 41 Radcliffe FC 1 Atherton Collieries AFC 0 M17:00 | 23/04/22 | R 42 Scarborough Athletic 5 Radcliffe FC 2 |
| 17 | |  G´borough Trinity | 42 | 12 | 14 | 16 | 40 | 52 | -12 | 50 | M18:00 | 26/03/22 | R 37 Hyde United 1 G´borough Trinity 0 B17:00 | 02/04/22 | R 38 G´borough Trinity 1 South Shields 1 G17:00 | 09/04/22 | R 39 G´borough Trinity 2 Mickleover FC 0 M17:00 | 16/04/22 | R 40 Scarborough Athletic 2 G´borough Trinity 0 B17:00 | 18/04/22 | R 41 G´borough Trinity 2 Grantham Town 2 G17:00 | 23/04/22 | R 42 Whitby Town 1 G´borough Trinity 2 |
| 18 | |  Hyde United | 42 | 14 | 8 | 20 | 52 | 65 | -13 | 50 | G18:00 | 26/03/22 | R 37 Hyde United 1 G´borough Trinity 0 G17:00 | 02/04/22 | R 38 Ashton United FC 0 Hyde United 3 M17:00 | 09/04/22 | R 39 Hyde United 0 Bamber Bridge 4 M17:00 | 16/04/22 | R 40 Grantham Town 2 Hyde United 0 B17:00 | 18/04/22 | R 41 Hyde United 2 Stalybridge Celtic 2 G17:00 | 23/04/22 | R 42 FC United Of Manchester 0 Hyde United 2 |
| 19 | |  Atherton Collieries AFC | 42 | 13 | 9 | 20 | 34 | 45 | -11 | 48 | M17:00 | 02/04/22 | R 38 FC United Of Manchester 2 Atherton Collieries AFC 0 B21:45 | 05/04/22 | R 33 Ashton United FC 2 Atherton Collieries AFC 2 B17:00 | 09/04/22 | R 39 Nantwich Town 2 Atherton Collieries AFC 2 M17:00 | 16/04/22 | R 40 Atherton Collieries AFC 0 Warrington Town 2 M17:00 | 18/04/22 | R 41 Radcliffe FC 1 Atherton Collieries AFC 0 B17:00 | 23/04/22 | R 42 Atherton Collieries AFC 1 Morpeth Town 1 |
| 20 | |  Basford United | 42 | 12 | 9 | 21 | 32 | 49 | -17 | 45 | B17:00 | 02/04/22 | R 38 Whitby Town 0 Basford United 0 M21:45 | 05/04/22 | R 33 Basford United 0 Warrington Town 1 M17:00 | 09/04/22 | R 39 Basford United 0 Matlock Town 1 G15:00 | 16/04/22 | R 40 Stafford Rangers 0 Basford United 1 M17:00 | 18/04/22 | R 41 Basford United 0 Mickleover FC 1 M17:00 | 23/04/22 | R 42 Witton Albion 4 Basford United 0 |
| 21 | |  Witton Albion | 42 | 12 | 7 | 23 | 48 | 78 | -30 | 43 | M17:00 | 02/04/22 | R 38 Bamber Bridge 2 Witton Albion 0 G21:45 | 05/04/22 | R 22 Witton Albion 3 Morpeth Town 2 G17:00 | 09/04/22 | R 39 Lancaster City 0 Witton Albion 1 G15:00 | 16/04/22 | R 40 Witton Albion 2 Radcliffe FC 1 M17:00 | 18/04/22 | R 41 Warrington Town 2 Witton Albion 0 G17:00 | 23/04/22 | R 42 Witton Albion 4 Basford United 0 |
| 22 | |  Grantham Town | 42 | 8 | 10 | 24 | 45 | 81 | -36 | 34 | M18:00 | 26/03/22 | R 37 Grantham Town 0 Whitby Town 2 M17:00 | 02/04/22 | R 38 Stafford Rangers 4 Grantham Town 1 M17:00 | 09/04/22 | R 39 Buxton FC 3 Grantham Town 0 G17:00 | 16/04/22 | R 40 Grantham Town 2 Hyde United 0 B17:00 | 18/04/22 | R 41 G´borough Trinity 2 Grantham Town 2 G17:00 | 23/04/22 | R 42 Grantham Town 1 South Shields 0 |
