Veton Tusha scored to make it 3-1 at the beginning of the second half but the Lions were in control and got an easy 6-1 win with goals by Muhammet Ozkal -own goal -- Younes Belhanda, Jesse Sekidika's goals.
Muslera underwent surgery after sustaining a tibula and fibula (tib-fib) fracture after colliding with Caykur Rizespor's forward Milan Skoda during a league match in June.
Galatasaray jumped to third place with 36 points while Yukatel Denizlispor is at the bottom of the standings with 14.
Wednesday results in Super Lig:
Atakas Hatayspor - Yeni Malatyaspor: 1-2
Caykur Rizespor - Gaziantep FK: 3- 0
Galatasaray - Yukatel Denizlispor: 6-1