Besiktas once again took the lead, this time with Georges Kevin N'Koudou, who scored a well-placed shot inside the penalty area.
Now with 75 points in 35 matches, the league leaders increased the lead to 3-1 in the 65th minute with N'Koudou again. Galatasaray, six points behind leaders Besiktas, had to win against Antalyaspor in an away match and delivered with Mostafa Mohammed.
After missing many chances, Galatasaray found the goal with Mohamed in the 77th minute, the Egyptian striker converted Sener Ozbayrakli's low cross inside the six-yard box.
Galatasaray increased their points total to 69, same with Fenerbahce.